A crash involving a number of vehicles - including a bus according to witnesses- has closed a stretch of the A64
The road is closed in both directions at Flaxton, near York.
North Yorkshire Police urges drivers to avoid the area and warn the road is likely to remain closed well into the night.
A statement from North Yorkshire Fire and Rescue added: “Fire appliances from York, Huntington, Acomb and Malton are currently at the scene of a serious road traffic collision on the A64 near the Flaxton junction.
“The incident has numerous vehicles involved.
“Police and ambulance also on scene.”