The A64 is closed in both directions at Rillington due to a serious crash.
Police and ambulances are at the scene.
Police are advising people to leave the road at Malton or Yeadingham to avoid delays.
The incident happened at around 3.40pm today, Friday 22 July 2016, and involved an HGV and 2 cars.
A North Yorkshire Police spokesman said: "A full road closure is now in place. The road will remain closed for several hours.
"Anyone travelling towards the East Coast will not be able to travel via the A64 and will need to exit the A64 at Malton. Those travelling from the East Coast will not be able to get any further than Yedingham on the A64.
"Anyone who witnessed the collision is asked to contact North Yorkshire Police. Dial 101, press 1 and pass information onto the force control room. Please quote reference number 0333 of today."