Both the eastbound and westbound carriageaway from Dunslow roundabout to Seamer will be full closed over night from Tuesday January 7 to Friday January 10.
The closures are in place to allow for carriageway improvements.
The road will be shut between 8pm and 6am.
Diversions routes will be in place and signposted.
The A64 eastbound and westbound carriageway at Knapton will be in narrow lanes until March for junction improvements.