It happened on Seamer Moor Lane at around 10.10am on Friday November 29.
It involved a blue Ford Ka and a black Vauxhall Corsa. The driver of the Corsa, a 17-year-old boy was taken to hospital with serious injuries where he remains in a stable condition.
The driver and passenger in the Ka, two women, were both taken to hospital. The passenger sustained serious injuries and the driver was less seriously injured.
Officers are appealing for any dash-cam footage and witnesses who saw either the vehicles prior to the crash or who witnesses the actual collision, to contact them.
Anyone with any information is asked to contact North Yorkshire Police on 101, or email [email protected]
Please quote reference 12190219028 when passing on information.
The road was closed while all three emergency services dealt with the incident. It reopened at around 1pm.