Harry Walmsley (68) took up the challenge with Elliot Hatton who struck an outstanding 118 which included 12 sixes.
The innings closed on a massive 397 for 8 with Joe Routh taking 3 for 83.
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Facing such a daunting target, the Cottingham innings failed to gain any real momentum and wickets soon fell at regular intervals.
James Berridge (41) and Cameron Furlong (28) offered resistance but the visitors finished 132 all out.
Elliot Hatton capped an exceptional all round performance taking 5 for 29.
Next week Flixton face Easingwold away.