Boro will be without defender Nathan Peat, who is suspended, though Fernando Moke returns to the squad after his ban was concluded.
Witton suffered relegation from the Evo-Stik Premier at the end of last season and they have made a below average start to the new campaign.
They have won their last two outings in all competitions, including a 2-1 win at Trafford in the league on Saturday and a 4-0 success against Northwich Manchester in the Cheshire FA Cup.
Joint-bosses Bryan Hughes and Paul Foot will be hoping their side can continue where they left off on Wednesday night when they beat Richmond Town 3-0 in the North Riding Cup.