After Newlands clinched the Sunday League Division One title last season, Trafalgar will be looking to reclaim the trophy as they kick off against Fylingdales.
Newlands open against newly-promoted Heslerton, who moved up in only their second season back in the Sunday League.
Fellow newly-promoted side Itis Itis United start at Commerical.
Barrowcliff host Whitby Wanderers to round up the first division’s opening ties.
West Pier start their campaign a week later, hosting Trafalgar.
Division Two sees three new teams compete as Crown Tavern travel to Ayton on the opening week alongside Barrowcliff Reserves, who go to Newlands Reserves.
First In Last Out host Alma in their debut game on the opening Sunday as they look to start life in The Scarborough News-sponsored league with a bang.
Defending champions Trafalgar Reserves play Cayton Corinthians, while Roscoes Bar host Fylingdales Reserves in the last of the Division Two opening fixtures.
Hull Uni begin a week later, hosting Mark Plumpton’s Ayton side.
Sunday September 6
Barrowcliff v Whitby Wanderers, Commercial v Itis Itis United, Newlands v Heslerton, Trafalgar v Fylingdales
Ayton FC v Crown Tavern, First In Last Out v Alma, Newlands Reserves v Barrowcliff Reserves, Roscoes Bar FC v Fylingdales Reserves, Trafalgar Reserves v Cayton Corinthians.
Tuesday September 8
Trafalgar Reserves v Fylingdales Reserves.
Thursday September 10
Whitby Wanderers v Trafalgar.
Sunday September 13
Fylingdales v Commercial, Itis Itis United v Barrowcliff,
West Pier v Trafalgar, Whitby Wanderers v Newlands.
Barrowcliff Reserves v Crown Tavern, Newlands Reserves v First In Last Out, Roscoes Bar v Trafalgar Reserves, Hull Uni v Ayton, Alma v Fylingdales Reserves.
Sunday September 20
Fylingdales v Newlands, Itis Itis United v Heslerton, Trafalgar v Commercial, West Pier v Barrowcliff.
Ayton FC v Newlands Reserves, Cayton Corinthians v Fylingdales Reserves, Crown Tavern v Hull Uni, First In Last Out v Roscoes Bar, Alma v Barrowcliff Reserves.
Sunday September 27
Barrowcliff v Trafalgar, Heslerton v Fylingdales, Newlands v West Pier, Whitby Wanderers v Itis Itis United.
Cayton Corinthians v Barrowcliff Reserves, Newlands Reserves v Crown Tavern, Roscoes Bar v Ayton, Hull Uni v Alma, Trafalgar Reserves v First In Last Out.