The home side scored a try on 10 minutes as Driffield turned defence into attack, stole a Scarborough lineout and after a flowing move, Joseph Robinson raced clear to touch down, with the conversion missed.
In the 24th minute,a handful of Scarborough errors allowed Ben Dinsdale to break down the wing to score and unconverted try to make it 10-0.
Seven minutes later, Scarborough lost a line-out on their line and the ball was spread wide and Benjamin Blacker scored in the corner, with the conversion missed again to make it 15-0.
On the stroke of half-time, Sam Jackson collected the ball, attempts to flick to Tom Harrison but Kyle Dench collected the loose ball to score. The conversion was kicked to put them 22-0 ahead.
In the 54th minute Jordan Wakeham became the first man sent to the sin-bin in the derby clash and three minutes later the home side took full advantage, Robinson scoring his second try, which was converted to hand them a 29-0 lead.
Despite also losing a man to the sin-bin, Driffield added another converted try in the 64th minute and a knock-on from Komiti Tuilagi allowed Ryan Longville through to make it 43-0 with another converted try.
Two minutes from time Jonty Holloway scored a consolation try in the corner, which Tom Ratcliffe converted as Driffield completed a 43-7 success.