The victim has been named as Andrew Turner, 58, whose initial injuries were not thought to be life-threatening.
Mr Turner was found with a "serious" head injury at a property on Marlborough Terrace at 1.15am on Thursday, August 26 after police responded to reports that a man had been assaulted.
Humberside Police have now launched a murder investigation after the 58-year-old died in hospital on Friday, September 3.
Post-war asbestos bungalows to be demolished in Scarborough as plans for new terraced homes approved
Vandalised Scarborough allotments to be restored as council approves plans to help tackle hundreds stuck on waiting lists
COURT: Scarborough brothers threw man around 'like a rag doll' during vicious street attacks
Filey man wanted by police after 'serious' assault and criminal damage incident
Scarborough seaweed farm SeaGrown win Government contract to help increase renewable energy
Mr Turner's family are being supported by specially trained officers and have asked for privacy at this time. A police spokesperson said: "Our thoughts are with Andrew’s family and friends at this difficult time."
A 19-year-old woman has been arrested and charged in connection with the assault.
Officers are appealing for anyone who may have information and has not already spoken to police to call 101 and quote reference number 16/85331/21.