North Yorkshire Police said the burglary happened on Royal Avenue in Scarborough between 2pm and 3pm on Saturday June 18.
A large green suitcase was reported stolen from the home after the owners returned from a holiday.
Officers are appealing for the public's help and any information of sightings of the suitcase and descriptions of anyone who was in possession of it.
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They are also urging anyone who may have CCTV, dash-cam or doorbell camera footage to come forward.
Anyone with information should email [email protected] or call North Yorkshire Police on 101, select option 2, and ask for Georgia Grainge.
Information can be passed on anonymously to Crimestoppers on 0800 555 111. Quote police reference number 12220105111 when providing information.