Emergency services are still at the scene of the two-vehicle crash on the A169 at Low Marishes, Malton.
A North Yorkshire Police spokesman said the incident involved two cars and that the road will remain closed for several hours.
They added: "Anyone who witnessed the incident is asked to call police. Dial 101, press 1 and pass information onto the force control room.
"Please quote reference number NYP-18082016-0179 when passing on information.