Daniel Ryan, 15, was last seen on Cardigan Road at 1pm yesterday, Monday, May 10.
Officers have so far been unable to locate or speak with Daniel, despite extensive searches.
Daniel is described as 5’11” tall, of a slim build, with shoulder long dark brown hair and brown eyes. He is believed to be wearing a black Slipknot hoodie, black leather jacket, black ripped jeans and black lace up boots.
Humberside Police are concerned for his safety and would appeal for anyone who sees him or knows where he is to contact police on 101 quoting log 425 of May 10.
A police spokesperson said: "Daniel if you see this, you are not in any trouble, we just want to make sure you’re okay and would ask that you get in touch."