Scarborough land white ball fixtures with Surrey and Northamptonshire set to visit North Marine Road
That is followed by the visit of Northamptonshire on Wednesday July 28.
The two one-day fixtures take the scheduled number of days of first class cricket at Scarborough in 2021 to six - with the highly anticipated Roses clash against Lancashire in the County Championship between Sunday 11 and Wednesday 14 July.
That could rise with a further four-day clash once Yorkshire's fixture list is confirmed.
The Royal London Cup final is set to be staged at Trent Bridge on 19 August with Somerset aiming to defend the title they won at Lord’s in 2019.
All Vitality Blast and Royal London Cup fixtures will be available via BBC Local Radio stations with extensive coverage also on 5 Live Sports Extra.
The men’s 50-over competition will be preceded with 20 matches between First-Class Counties and National Counties from 20-22 July.
ECB managing director of county cricket, Neil Snowball, said: “The stage is set for an exciting and important summer of domestic cricket for the First-Class Counties and the women’s regional teams.
“I know how much county members and supporters eagerly anticipate the release of fixtures and I am pleased that we have been able to plan a complete schedule for men’s and women’s cricket.
“The Vitality Blast has established itself as a much-loved tournament while the return of the Royal London Cup, alongside the remodelled County Championship for this season, will be warmly welcomed as we all look forward to the summer.
“I am also delighted that we will shortly release the schedule for the women’s Regional 50 over and T20 competitions.
"These competitions will not only showcase the deepening pool of talent in women’s cricket, but also further strengthen the professional pathway for our female players.”
The health and safety of anyone attending matches this summer will remain the priority of the ECB and the First-Class Counties.
The ECB continues to work closely with Government, and other sports, as it plans ways to safely welcome supporters back to venues across England and Wales this summer.
To sync this summer's domestic fixtures automatically to the calendar of your mobile phone and digital devices, click on this link: http://ql.e-c.al/DomesticFixturesRoyal London Cup Groups & Schedule
2021 Royal London Groups
Group A: Essex, Worcestershire, Sussex, Middlesex, Kent, Durham, Gloucestershire, Hampshire, Lancashire
Group B: Leicestershire, Derbyshire, Glamorgan, Yorkshire, Surrey, Warwickshire, Nottinghamshire, Northamptonshire, Somerset.
The groups for the Royal London Cup were randomly drawn. The order that they were drawn appears in the above list and has determined the home and away ties.
Example: The first team in the Group will play at home to the second, third, fourth and fifth teams drawn, and away to sixth, seventh, eighth and ninth.
This continues – another example is the team drawn seventh; this team will play at home to teams drawn eighth, ninth, first, second, and away to teams drawn third, fourth, fifth, sixth.
Group Stage: 22 July – 12 August
Knockout Stage: Quarter-finals: 14 August; Semi-Finals: 17 August. Final: 19 August at Trent Bridge.