Leaders Pier will be confident of claiming all three points at second-from-bottom Cayton, while Edgehill, who are nine points behind the leaders but have two games in hand on Pier, entertain third-from-bottom Whitby Fishermen.
On Sunday, the top-flight teams lock horns in the Senior Cup quarter-finals.
Holders West Pier travel to Ayton, while Newlands play host to Roscoes Bar, Cayton entertain FILO and Heslerton make the long trip north to Fylingdales.
In the league, Angel Athletic can confirm their second division title success with a home win against Ayton Reserves.
League Cup quarter-final (1.30pm ko)Hunmanby United v Newlands
League Trophy quarter-final (1.30pm ko)Sherburn v Eastway Sports
Division One (2pm ko)Cayton v West Pier, Edgehill v Whitby Fishermen, Seamer v Filey Town
Division Two (2pm ko)Falsgrave Athletic v Duchess, FC Rosette v West Pier Reserves, Filey Town Reserves v Snainton, Goalsports v Seamer Reserves, Newlands Reserves v Edgehill Reserves, Scalby v Cayton Reserves
Division Three (2pm ko)Ayton v Goalsports Reserves, Fishburn Park Reserves v Commercial, Goldsborough United v Seamer 3rds, Hunmanby United Reserves v Edgehill 3rds, Itis Itis Rovers v Scalby Reserves
Senior Cup quarter-finals (10.30)Ayton v West Pier, Cayton v FILO, Fylingdales v Heslerton, Newlands v Roscoes Bar.
Scarborough Sunday League Division Two (10.30am)Angel Athletic v Ayton Reserves, Scalby v Scarborough Campus.