Unable to speak, Lost Voice Guy - real name Lee Ridley - is the first stand-up comedian in Britain to use a communication aid in his routines.
Also on the bill in Whitby are Geoff Norcott, Ant Dewson and compere Thomas Green.
Tickets £12 in advance – visit www.funhousecomedy.co.uk for information and bookings.
Doors open at 7pm and the show is due to start at 8pm.