The purpose-built, state-of-the-art building has to look its best when it opens to the public for a couple of hours, from 10am to noon.
Thousands of RNLI supporters are expected to turn out for the occasion.
A team of five has been despatched to RNLI HQ in Poole and will bring the Shannon to Scarborough over four days, with stopovers in Dover, Lowestoft and Hull.
The team is coxswain Tom Clark, second coxswain Lee Marton, mechanic and deputy second coxswain Dave Horsley, deputy second coxswain and mechanic Dave Jackson and navigator / coxswain Heath Samples.
The Â£2m boat has been funded by donations from the FW Plaxton Charitable Trust.
The Shannon, named Frederick William Plaxton after its benefactor, is due to arrive at 1.15pm, as its fleet number is 13-15. High tide is at 3pm.It will be escorted by the outgoing Mersey boat.